Aims and Scope

The Open Biochemistry Journal is an open-access online journal dedicated to the rapid publication of original research articles, reviews/mini-reviews, letters and guest edited single topic issues in all sub-disciplines of biochemistry (including genomics, gene expression, replication, proteomics, structural biology, enzymology, bioenergetics, metabolism, signal transduction, bioinformatics, cell biology, glycoscience, glycobiology, glycochemistry, glycotechnology, pharmacology, enzyme inhibition, inhibitory processes, immunochemistry, macromolecules, biopolymers, and nitric oxide). The journal publishes clearly written articles describing significant advances in the field that are of great interest for the scientific community worldwide. Non-conclusive or confirmatory studies are not accepted.


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Study of the Interaction of Zinc Cation with Azithromycin and its Significance in the COVID-19 Treatment: A Molecular Approach

Jacques H. Poupaert, Blanche Aguida, Codjo Hountondji

Introduction:

On account of the current COVID-19 pandemic, we have explored the importance of azithromycin and zinc in the treatment of the coronavirus disease by studying the interaction between the cation Zn++ and azithromycin with the tools of the semi-empirical quantum mechanics PM3 method.

Methods:

By this approach, the niche in which Zn++ is located was determined. Zn++ creates a strong clastic binding between an amine and a hydroxyl group located on the amino-hexose side-chain. Such an interaction serves as a shuttle and allows zinc cation to invade endocellular structures.

Results:

In this triple collaborative association, the role of hydroxychloroquine would be more that of a chaotropic agent at plasmic membranes, which facilitates access to the azithromycin-Zn++ equipage into key internal compartments.

Conclusion:

Finally, we show that both azithromycin and Zn++ are susceptible to play a direct role against the replication and the assembly of SARS-CoV-2 particles.


September 22, 2020
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