Certain Diet and Lifestyle May Contribute to Islet β-cells Protection in Type-2 Diabetes via the Modulation of Cellular PI3K/AKT Pathway



Yasuko Kitagishi*, #, Atsuko Nakanishi*, #, Akari Minami*, #, Yurina Asai, Mai Yasui, Akiko Iwaizako, Miho Suzuki, Yuna Ono, Yasunori Ogura , Satoru Matsuda*, #
Department of Food Science and Nutrition, Nara Women's University, Kita-Uoya Nishimachi, Nara 630-8506, Japan


Article Metrics

CrossRef Citations:
2
Total Statistics:

Full-Text HTML Views: 411
Abstract HTML Views: 171
PDF Downloads: 99
Total Views/Downloads: 681
Unique Statistics:

Full-Text HTML Views: 250
Abstract HTML Views: 101
PDF Downloads: 65
Total Views/Downloads: 416



© Kitagishi et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Department of Food Science and Nutrition, Nara Women's University, Kita-Uoya Nishimachi, Nara 630-8506, Japan; Tel: +81 742 20 3451; Fax: +81 742 20 3451; E-mail: smatsuda@cc.nara-wu.ac.jp
# These four authors contributed equally to this work.


Abstract

PI3K/AKT pathway has been shown to play a pivotal role on islet β-cell protection, enhancing β-cell survival by stimulating cell proliferation and inhibiting cell apoptosis. Accordingly, this pathway appears to be crucial in type-2 diabetes. Understanding the regulations of this pathway may provide a better efficacy of new therapeutic approaches. In this review, we summarize advances on the involvement of the PI3K/AKT pathway in hypothetical intra-cellular signaling of islet β-cells. As recent findings may show the nutritional regulation of the survival pathway in the islet β-cells through activation of the PI3K/AKT pathway, we also review studies on the features of several diets, correlated lifestyle, and its signaling pathway involved in type-2 diabetes. The molecular mechanisms contributing to the disease are the subject of considerable investigation, as a better understanding of the pathogenesis will lead to novel therapies against a condition of the disease.

Keywords: AKT, GSK3β cell signaling, islet β-cells, type-2 diabetes, PI3K.