REVIEW ARTICLE


Role of Immunoinformatics in Accelerating Epitope-Based Vaccine Development against Dengue Virus



Ahmad Husein Alkaff1
iD
, Mutiara Saragih1
iD
, Mochammad Arfin Fardiansyah1
iD
, Usman Sumo Friend Tambunan1, *
iD

1 Department of Chemistry, Universitas Indonesia, Kampus UI Depok 16424, Depok, Jawa Barat, Indonesia


© 2020 Alkaff et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at Bioinformatics Research Group, Department of Chemistry, Universitas Indonesia, Kampus UI Depok 16424, Depok, Jawa Barat, Indonesia; E-mail: usman@ui.ac.id


Abstract

Dengue Fever (DF) has emerged as a significant public health problem of international concern with its high prevalence in the tropic and subtropical regions. Dengue Virus (DENV), which is the cause of DF, consists of four serotypes of antigenically distinct viruses. The immense variation and limited identity similarity at the amino acid level lead to a problematic challenge in the development of an efficacious vaccine. Fortunately, the extensively available immunological data, the advance in antigenic peptide prediction, and the incorporation of molecular docking and dynamics simulation in immunoinformatics have directed the vaccine development towards the rational design of the epitope-based vaccine. Here, we point out the current state of dengue epidemiology and the recent development in vaccine development. Subsequently, we provide a systematic review of our validated method and tools for B- and T-cell epitope prediction as well as the use of molecular docking and dynamics in evaluating epitope affinity and stability in the discovery of a new tetravalent dengue vaccine through computational epitope-based vaccine design.

Keywords: Dengue virus, Epitope-based vaccine, Antigen discovery, Immunoinformatics, In-silico vaccine design, Molecular docking simulation, Molecular dynamics simulation.