β-Glucan Improves Conditions of Chronic Fatigue in Mice by Stimulation of Immunity

Vaclav Vetvicka1, *, Jana Vetvickova1
1 Department of Pathology, University of Louisville, Louisville, KY, USA

© 2019 Vetvicka and Vetvickova .

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Department of Pathology, University of Louisville, Louisville, KY 40202, USA; Tel: 5028521612; Fax: 502-852-1177 E-mail:



Various natural molecules have been studied for the enhancement of physical endurance. Glucan has been found to improve various stress-related conditions and to improve fatigue and endurance.


In this study, we evaluation of glucan effects on some reactions involved in chronic fatigue has been focused.


Phagocytosis of neutrophils, the production of IL-2, IL-4, and IL-10 by spleen cells, and levels of antioxidant glutathione and oxidative stress marker superoxide dismutase in brain were measured. In addition, the effects of glucan on water immersion and on rotarod were also measured.


The glucan supplementation strongly improved the suppressed phagocytosis and changes in cytokine and levels of oxidative stress markers caused by fatigue. In addition, glucan supplementation also increased the motor functioning of tested animals.


Our data suggested that anti-fatigue properties of glucan are related to its well-established effects as stimulator of immune reactions.

Keywords: Glucan, Immunity, Fatigue, Cytokine, Immune reaction, Antioxidant glutathione.