RESEARCH ARTICLE

Acute Phase Response: Implication in ST-segment Elevation Myocardial Infarction

Esin Eren1 Hamit Yasar Ellidag2 Akar Yılmaz3 Özgür Aydın4 Necat Yılmaz2 , * Open Modal Authors Info & Affiliations
The Open Biochemistry Journal • 16 May 2014 • RESEARCH ARTICLE • DOI: 10.2174/1874091X01408010044

Abstract

We aimed to investigate the relation between serum inflammatory markers, 25OHvit-D3 and oxidative stress markers, namely paraoxonase1-arylesterase (PON1-ARE), total antioxidant status (TAS) and total oxidant status (TOS) in 30 male patients with ST–elevation myocardial infarction(STEMI) . There was negative correlation between tumor necrosis factor alpha and ARE; positive correlations between serum amyloid A(SAA) and oxidative stress index, SAA and TOS, 25OHvit-D3 and ARE. There was no statistically significant correlation between inflammation makers, oxidative stress markers and Gensini score. The main finding of our study was the tendency of inflammation markers, and oxidative stress markers, to change in relatively clear opposite directions in STEMI.

Keywords: : Acute coronary syndrome, calcidiol, HDL, IL-6, IL-10, inflammation markers, oxidative stress, paraoxonase, serum amyloid A, vitamin D.
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