Acute Phase Response: Implication in ST-segment Elevation Myocardial Infarction



Esin Eren1, Hamit Yasar Ellidag2, Akar Yılmaz3, Özgür Aydın4, Necat Yılmaz2, *
1 Antalya Public Health Center of Ministry of Health, Antalya, Turkey
2 Central Laboratories of Antalya Education and Research Hospital of Ministry of Health, Antalya, Turkey
3 Cardiology of Antalya Education and Research Hospital of Ministry of Health, Antalya, Turkey
4 Maternity and Children’s Hospital, Batman, Turkey


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© Eren et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Antalya Education and Research Hospital, Clinical Biochemistry Central Laboratory Ministry of Health, Antalya Egitim ve Arastirma, Hastanesi Varlik Mahallesi Kazim Karabekir Caddesi Soguksu 07050, Antalya, Turkey; Tel: 00902422494400; Fax: +902422494462; E-mail: necatyilmaz@hotmail.com


Abstract

We aimed to investigate the relation between serum inflammatory markers, 25OHvit-D3 and oxidative stress markers, namely paraoxonase1-arylesterase (PON1-ARE), total antioxidant status (TAS) and total oxidant status (TOS) in 30 male patients with ST–elevation myocardial infarction(STEMI) . There was negative correlation between tumor necrosis factor alpha and ARE; positive correlations between serum amyloid A(SAA) and oxidative stress index, SAA and TOS, 25OHvit-D3 and ARE. There was no statistically significant correlation between inflammation makers, oxidative stress markers and Gensini score. The main finding of our study was the tendency of inflammation markers, and oxidative stress markers, to change in relatively clear opposite directions in STEMI.

Keywords: : Acute coronary syndrome, calcidiol, HDL, IL-6, IL-10, inflammation markers, oxidative stress, paraoxonase, serum amyloid A, vitamin D.