RESEARCH ARTICLE


Effect of Peppermint Oil on Serum Lipid Peroxidation and Hepatic Enzymes after Immobility Stress in Mice



Abdoljalal Marjani*, 1, Reza Rahmati2, Azad Reza Mansourian1, Gholamreza Veghary1
1 Department of Biochemistry and Biophysics and Nutrition, Biochemistry and Metabolic Disorder Research Center, Golestan University of Medical Sciences, Golestan province, Gorgan, Iran
2 Department of Physiology, Faculty of Medicine, Golestan University of Medical Sciences, Golestan province, Gorgan, Iran


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© Marjani et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http: //creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Department of Biochemistry and Biophysics and Nutrition, Biochemistry and Metabolic Disorder Re-search Center Golestan province, Gorgan, Iran; Tel: 0981714421651; Fax: 00981714440225; E-mail: abdoljalal@yahoo.com


Abstract

This study was undertaken to determine the influences of various doses of peppermint oil on the hepatic en-zymes, alanine transaminase, apartate tranaminase, alkaline phosphotase and gamma glutamyl transferase and the level of malondialdehyde in the serum of mice with and without immobility stress. The mice exposed to drink water, 0.9, 27 and 60 mg/kg peppermint oil from the days 1 to 5 for a period of 4 h before and after immobility stress. Serum MDA in-creased in treatment group II, III and IV after immobility stress. There was a significant decrease in ALT in treatment group III and IV after immobility stress. There were also significant decreases in ALP and GGT in treatment group IV af-ter immobility stress. This result may suggest that, MDA level is higher in immobilization stress group than in the un-immobilized animals in serum and this results show that enzyme activities decreased after immobilization stress.

Keywords: Peppermint oil, lipid peroxidation, hepatic enzymes, immobility stress.