Subunit Mobility and the Chaperone Activity of Recombinant αB-Crystallin

Krushelnitsky, A; Mukhametshina, N; Gogolev, Y; Tarasova, N; Faizullin, D; Zinkevich, T; Gnezdilov, O; Fedotov, V

Subunit Mobility and the Chaperone Activity of Recombinant αB-Crystallin

A Krushelnitsky^{*, 1}, N Mukhametshina¹, Y Gogolev¹, N Tarasova¹, D Faizullin¹, T Zinkevich², O Gnezdilov², V Fedotov¹

¹ Kazan Institute of Biochemistry and Biophysics, Russian Academy of Sciences, Kazan, Russia

² Kazan Physical-Technical Institute, Russian Academy of Sciences, Kazan, Russia

Article Information

Identifiers and Pagination:

Year: 2008
Volume: 2
First Page: 116
Last Page: 120
Publisher ID: TOBIOCJ-2-116
DOI: 10.2174/1874091X00802010116

Article History:

Received Date: 31/7/2008
Revision Received Date: 5/8/2008
Acceptance Date: 6/8/2008
Electronic publication date: 2/9/2008
Collection year: 2008

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© Krushelnitsky et al; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http: //creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

^* the Kazan Institute of Biochemistry and Biophysics, Russian Academy of Sciences, Kazan, Russia;E-mail: krushelnitsky@mail.knc.ru

The comparison of the chaperone-like activity of native and covalently cross-linked human αB-crystallins has confirmed the important role of the subunit mobility in the chaperoning mechanism. Our data clearly demonstrate that the chaperone-like activity of α-crystallin is not only a surface phenomenon as was suggested by some researchers.

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RESEARCH ARTICLE

Subunit Mobility and the Chaperone Activity of Recombinant αB-Crystallin

Article Information

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Article History:

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Abstract

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Published Contents

About the Editor

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