Subunit Mobility and the Chaperone Activity of Recombinant αB-Crystallin
A Krushelnitsky*, 1, N Mukhametshina1, Y Gogolev1, N Tarasova1, D Faizullin1, T Zinkevich2, O Gnezdilov2, V Fedotov1
Identifiers and Pagination:Year: 2008
First Page: 116
Last Page: 120
Publisher ID: TOBIOCJ-2-116
Article History:Received Date: 31/7/2008
Revision Received Date: 5/8/2008
Acceptance Date: 6/8/2008
Electronic publication date: 2/9/2008
Collection year: 2008
open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http: //creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
The comparison of the chaperone-like activity of native and covalently cross-linked human αB-crystallins has confirmed the important role of the subunit mobility in the chaperoning mechanism. Our data clearly demonstrate that the chaperone-like activity of α-crystallin is not only a surface phenomenon as was suggested by some researchers.