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Linking Interaction between Antimicrobial Peptide and High Motility Group Box-1 (HMBG-1) in Bacterial Infection
The Open Biochemistry Journal
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19 Mar 2024 •
REVIEW ARTICLE
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DOI: 10.2174/011874091X277312231123093133
Abstract
Antimicrobial peptides (AMPs) are small proteins that protect against bacterial and fungal infections. Various organisms, including plants, animals, and bacteria, produce them. The HMGB-1 (HMGB-1) protein is produced by both immune cells and bacteria, and its main role is to facilitate the recognition of foreign agents, such as bacteria, by the immune system. AMP can protect against infections by interacting with HMGB-1. This enhances their protective capabilities and reduces inflammation associated with bacterial infections.
Keywords: HMGB-1, Antimicrobial peptide, AMP, Cathelicidin, Defensin, Bacterial infection.
