Genetic Polymorphism of Cytochrome p450 (2C9) Enzyme in Iranian Baluch Ethnic Group



Mojdeh Ghiyas Tabari1, Fatemeh Naseri2, Maryam Agh Ataby3, Abdoljalal Marjani4, *
1 Babol University of Medicine Sciences, Babol, Mazandaran province, Iran
2 Chabahar-Sistane and Baluchestan Province, Iran
3 Fatima Alzahra Hospital Minodasht, Golestan University of Medical Sciences, Gorgan, Golestan Province, Iran
4 Department of Biochemistry and Biophysics, Metabolic Disorders Research Center, Gorgan Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Golestan province, Iran


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© Tabari et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Department of Biochemistry and Biophysics, Metabolic Disorders Research Center, Gorgan Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Golestan province, Iran. Tel: +98(171)4421651; Fax: +98(171)4440225; E-mail: abdoljalal@yahoo.com


Abstract

The aim of the present study is to assess and compare the frequencies of the cytochrome P450 CYP2C9 variations in the Baluch ethnic group (n=110) with other ethnic groups. The allele frequencies of CYP2C9*1, CYP2C9*2 and CYP2C9*3 were 80.90%, 11.82% and 7.27%, respectively. 70.90%, 11.82%, 8.18%, 4.55%, 2.73% and 1.82% of subjects were with CYP2C9*1/*1, CYP2C9*1/*2, CYP2C9*1/*3, CYP2C9*2/*2, CYP2C9*2/*3 and CYP2C9*3/*3 genotypes, respectively. Different mutants may effect on prediction of drug dose requirements in different ethnic groups. Thus, CYP2C9 variants to be determined for findings high risk groups use optimal dosage of drugs metabolized by this polymorphic enzyme.

Keywords: Baluch ethnic group, CYP2C9 genetic polymorphism, polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP).