Hypothetical Two-Step Initiation of Experimental Carcinogenesis by Polycyclic Aromatic Hydrocarbons and Aminoazo Dyes
Identifiers and Pagination:Year: 2012
First Page: 40
Last Page: 42
Publisher ID: TOBIOCJ-6-40
Article History:Received Date: 19/2/2012
Revision Received Date: 29/3/2012
Acceptance Date: 30/3/2012
Electronic publication date: 27/4/2012
Collection year: 2012
open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http: //creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
A new hypothesis is discussed, which describes the initiation of the carcinogenesis through polycyclic aromatic hydrocarbons (PAHs) and aminoazo dyes (AZOs) as a two-step process: the oncogenic proteins of the ras or ras-like on-cogenes activated by mutation (“initiation A ”) co-operate with the complexes in the plasma membrane formed during the "initiation B " stage from the parent compounds of the PAHs or AZOs with cholesterol and apolipoprotein A-I. The final result of this co-operation, or the "complete initiation", is an irreversibly modified membrane architecture with negative consequences for growth control.