Hypothetical Two-Step Initiation of Experimental Carcinogenesis by Polycyclic Aromatic Hydrocarbons and Aminoazo Dyes



Bodo Contag*
Beuth Hochschule für Technik Berlin; Fachbereich II; Pharma- und Chemietechnik Luxemburger Str. 10; 13353 Berlin, Germany


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© Bodo Contag; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http: //creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Beuth Hochschule für Technik Berlin; Fachbereich II; Pharma- und Chemietechnik; Luxemburger Str.10; 13353 Berlin, Germany; Tel. +49 (030) 8326612; Fax: +49 (030) 74699894; E-mail: Bodo.Contag@gmx.de


Abstract

A new hypothesis is discussed, which describes the initiation of the carcinogenesis through polycyclic aromatic hydrocarbons (PAHs) and aminoazo dyes (AZOs) as a two-step process: the oncogenic proteins of the ras or ras-like on-cogenes activated by mutation (“initiation A ”) co-operate with the complexes in the plasma membrane formed during the "initiation B " stage from the parent compounds of the PAHs or AZOs with cholesterol and apolipoprotein A-I. The final result of this co-operation, or the "complete initiation", is an irreversibly modified membrane architecture with negative consequences for growth control.

Keywords: Initiation of carcinogenesis, polycyclic aromatic hydrocarbons, aminoazo dyes..