Nitric Oxide Balance in Health and Diseases: Implications for New Treatment Strategies
Musbau A. Akanji1, Anne A. Adeyanju2, Damilare Rotimi3, Oluyomi S. Adeyemi3, *
Identifiers and Pagination:Year: 2020
First Page: 25
Last Page: 32
Publisher ID: TOBIOCJ-14-25
Article History:Received Date: 24/2/2020
Revision Received Date: 10/5/2020
Acceptance Date: 11/5/2020
Electronic publication date: 31/07/2020
Collection year: 2020
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Nitric Oxide (NO) is an essential signaling molecule with diverse physiological functions in humans. The steady-state concentration and site of production of nitric oxide determine its effects in biological systems. The human cells are exposed to both beneficial and harmful effects of NO. These dual effects of NO could depend on its local concentration in the cells. Additionally, the rate of synthesis, translocation, direct interaction with other molecules, and signals contribute to the biochemical and physiological effects of NO. In this review, the biochemical and physiological role of NO, particularly in health and disease as touching on cell signaling, oxidative stress, immunity, as well as cardiovascular protection amongst others, is focused on. Therefore, this review objectively discusses the dual functionality of NO in living cells.