RESEARCH ARTICLE
Histidine Residues at the Active Site of the Pasteurella multocida Toxin
Gillian D Pullinger#, Alistair J Lax*
Article Information
Identifiers and Pagination:
Year: 2007Volume: 1
First Page: 7
Last Page: 11
Publisher ID: TOBIOCJ-1-7
DOI: 10.2174/1874091X00701010007
Article History:
Received Date: 17/5/2007Revision Received Date: 31/5/2007
Acceptance Date: 4/6/2007
Electronic publication date: 15/6/2007
Collection year: 2007

Abstract
We have investigated histidine residues near the active site of the mitogenic Pasteurella multocida toxin. Mutation of H1202 or H1228 had little effect, while the effect of mutation on H1223 depended on the amino acid substituted. Mutation of H1205 caused complete loss of activity, indicating its importance in PMT activity.