Histidine Residues at the Active Site of the  Toxin

Pullinger, Gillian D; Lax, Alistair J

Histidine Residues at the Active Site of the Pasteurella multocida Toxin

Gillian D Pullinger^#, Alistair J Lax^*

King’s College London, Dental Institute, Department of Microbiology, London SE1 9RT, UK

^# Present address: Institute for Animal Health, Compton, Newbury, Berkshire, RG20 7NN, UK

Article Information

Identifiers and Pagination:

Year: 2007
Volume: 1
First Page: 7
Last Page: 11
Publisher ID: TOBIOCJ-1-7
DOI: 10.2174/1874091X00701010007

Article History:

Received Date: 17/5/2007
Revision Received Date: 31/5/2007
Acceptance Date: 4/6/2007
Electronic publication date: 15/6/2007
Collection year: 2007

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2007 Bentham Science Publishers Ltd

^* Address correspondence to this author at the King’s College London Dental Institute, Department of Microbiology, London SE1 9RT, UK; E-mail: alistair.lax@kcl.ac.uk

We have investigated histidine residues near the active site of the mitogenic Pasteurella multocida toxin. Mutation of H1202 or H1228 had little effect, while the effect of mutation on H1223 depended on the amino acid substituted. Mutation of H1205 caused complete loss of activity, indicating its importance in PMT activity.

Keywords: Pasteurella multocida, toxin, PMT, domain structure, histidine residues, G-proteins.

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RESEARCH ARTICLE

Histidine Residues at the Active Site of the Pasteurella multocida Toxin

Article Information

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Abstract

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